Prism Exos
WELCOME TO Prism Exos
ELEVATING HEALTHCARE THROUGH SCIENTIFIC INNOVATION
At Prism Exos, we stand at the forefront of the science and technology industry, pioneering groundbreaking innovations to redefine healthcare. Our product range is meticulously crafted not only to enhance physical and mental performance but also to elevate energy levels and overall vitality, delivering tangible benefits for both patients and practitioners.
Our Vision: Cultivating Bio-Wellness for Holistic Well-Being
Our overarching goal is to foster a culture of bio-wellness, seeking harmony within the mind, body, and cellular processes. Through comprehensive education, we aim to kindle a passion for optimizing bodily functions, improving health, and unlocking an individual’s fullest potential.
The Heart of Our Offerings: MSC Exosome Product Line
Central to our offerings is the MSC exosome product line. These exceptional exosomes are intricately designed to elevate the body’s performance, enabling individuals to achieve health and life goals with unprecedented efficacy.
Firm Beliefs: Balance and Vitality for a Fulfilling Life
At Prism Exos, we firmly believe that balance and vitality are the cornerstones of a fulfilling life. We are wholly dedicated to providing the necessary tools and knowledge for individuals to embark on transformative journeys toward better health and well-being.
Exosomes
Powerful regenerative message in an extremely small packages
Figure X. Second degree burns in patient with Skin Type VI (left). Seven days after application of Prism Exos (middle). Sixty days after application of Prism Exos (right), with no scarring or abnormal pigmentation.
Exosomes are nano-scale extracellular vesicles - very small packages of signaling information one thousandth the size of a cell. They are produced by virtually every cell type as a means of intercellular communication. This natural paracrine signaling system allows a healthy body to run like a well-oiled machine.
Exosomes contain proteins such as growth factors, enzymes, receptors, transcription factors and matrix proteins that govern cell structure, function and signaling. They also contain messenger RNA (mRNA), the blueprint for protein production, and micro RNA (miRNA), an important intracel- lular signaling mediator. Having the same type of membrane as their parent cells, exosomes protect these exosomal proteins and miRNA from degradation until they are delivered to the target cell.
When exosomes deliver their contents to target cells, exosomal proteins can have direct effects on intracellular processes and signaling. Exosomal mRNA may be translated by the target cell to produce numerous copies of regenerative protein. Exosomal miRNA influences target cell protein production by interfering with specific endogenous protein production. Exosomal signaling can also alter target cell exosome loading for cascading effects and a more sustained effect than the type of proteins in PRP or amniotic fluid alone could be achieved.
Prism Exos
24 Hr Delivery
3rd Party Virology Test
Prism Exos®
Prism ExosⓇ is a purified mesenchymal stem cell (MSC)-derived exosome product that contains a multitude of growth factors that can enhance the coordinated cascade of cellular and biochemical events involved in natural wound healing and skin rejuvenation/regeneration.
The physiologic effects of the exosomal growth factors in Prism ExosⓇ can be used to stimulate healing of acute and chronic wounds, regenerate collagen in aging and damaged skin and reduce inflammation. Prism Exos® has the potential to accelerate wound healing, improve skin texture, reduce scarring, stimulate hair growth and shorten recovery time after cosmetic procedures.
Prism ExosⓇ is a cell-free isolate of MSC exosomes. This concentrated biologic product is sterile-filtered and re-suspended in [0.9%] normal saline. Each milliliter of Prism ExosⓇ contains 20 billion MSC exosomes.
Figure 1. Characterization of exosomes from different sources
Figure 2. Second degree burn one week after injury (left). Seven days after application of Prism ExosⓇ (middle). Four weeks after application of Prism ExosⓇ (right). Courtesy of Gregory Chernoff MD.
Mesenchymal Stem Cell Exosomes
This very unique type of exosomes are produced by stem cells of the connective tissue lineage the origin of skin, hair, bone, muscle, cartilage etc. MSC exosomes are very different than exosomes found in adult bone marrow, which has a preponderance of hematopoietic stem cell exosomes, or amniotic fluid, which has primarily maternal epithelial cell exosomes. The distinct ability of MSC exosomes to induce connective tissue synthesis may be the basis of many of the remarkable clinical benefits that have been observed with stem cell therapy.
Advantages of Young Progenitor Cells
As we age, the number and function of the MSCs in our tissues declines sharply. Aged autologous progenitor cells produce about 30% of the cytokines and significantly different miRNAs compared with peri-natal MSCs. This substantial difference in secretome confers a significant advantage of peri-natal MSC exosomes over exosomes from aged autologous or allogeneic progenitor cells.
Effects of MSC exosomes on Skin
- Stimulate fibroblast proliferation and migration;
- Promote angiogenesis in acute and chronic wounds;
- Increase collagen extracellular matrix production/ deposition;
- Modulate inflammation and immune response;
- Regulate tissue remodeling to reduce scarring:
- Increase the number of hair follicles in the growth phase;
- Regenerate dermal papilla cells of hair follicle.
SCAR REJUVENATION AND WOUND CURATION
At Prism Exos, we take pride in offering cutting-edge therapeutic solutions for scarless wound restoration. Our MSC exosomes play a pivotal role in this process by controlling the ratios of collagen and fibroblast differentiation. This control significantly reduces the likelihood of scarring, making our exosomes a revolutionary approach to wound healing.
MSC exosomes support the rebuilding of cutaneous wounds in a way that promotes scarless outcomes. These tiny vesicles facilitate tissue growth, regenerate injured tissues, and actively engage in the process of tissue regeneration. This unique mechanism accelerates the healing process, delivering results that go beyond conventional treatments.
MSC exosomes support the rebuilding of cutaneous wounds in a way that promotes scImportantly, MSC exosomes offer several advantages. They act as powerful mediators, orchestrating cellular processes without the need for stem cells. This makes our exosome therapy safe and highly effective. Furthermore, MSC exosomes don’t contain DNA, minimizing the risk of adverse immune responses.arless outcomes. These tiny vesicles facilitate tissue growth, regenerate injured tissues, and actively engage in the process of tissue regeneration. This unique mechanism accelerates the healing process, delivering results that go beyond conventional treatments.
Our commitment to advancing regenerative medicine is exemplified by the innovative use of MSC exosomes in scarless wound restoration. Prism Exos MSC exosomes represent a groundbreaking approach to wound healing and tissue regeneration, setting new standards in the field.
Anti- Inflammatory
By down-regulating inflam- matory proteins and upregu- lating anti-inflammatory proteins, MSC exosomes can reduce inflammation, which is a central mechanism of many autoimmune, inflammatory and degenerative conditions, as well as scarring.
Figure 3. Rosacea (left), two days after application of Prism ExosⓇ (right).
Regenerative
MSC exosomes stimulate the proliferation and migration of cells such as fibroblasts, endothelial cells, keratinocytes and specific endogenous progenitor cells that are involved in healing damaged tissues to increase angiogenesis (new blood vessel formation), improve survival of damaged tissues, accelerate wound healing and skin regeneration, and reduce scarring.
Figure 4. Healed incisions after keloid excisions with (left) and without (right) application of Prism Exos®. Gregory Chernoff MD
What Are Exosomes
Exosomes, these remarkable entities, are intricately involved in cellular communication and regenerative processes. They are minute vesicles originating from various cell types, including stem cells. These tiny packages are bestowed with an extraordinary capacity to contain and transport a diverse range of bioactive molecules.
Within the confines of exosomes lie substantial quantities of growth factors, cytokines, and an array of other bioactive substances. It’s this rich molecular payload that imparts upon exosomes their unique regenerative potential. What truly sets exosomes apart is their exceptional structure that enables them to transfer these bioactive cargo to neighboring cells.
This transfer of regenerative signals is pivotal in the world of cellular health. Exosomes act as nature’s messengers, facilitating intercellular communication. When they fuse with target cells, they deliver their payload, thereby kickstarting processes that promote tissue repair, regeneration, and growth.
How They Work
Stem cell-derived exosomes are the unsung heroes of regenerative medicine, orchestrating the body’s healing processes in a fascinating way. Here’s a closer look at how they work:
1. Identification of Injury: When tissue is injured, it releases chemical markers indicating the extent of damage. These markers act as distress signals.
2. Stem Cell Response: Stem cells, with their remarkable sensing abilities, pick up on these signals. They “know” that specific repair components are needed.
3. Customized Healing Components: Stem cells swing into action, producing the precise components required for healing the injured tissue. This includes growth factors, cytokines, and more.
4. Packaging in Exosomes: These components are meticulously packaged into tiny vesicles known as exosomes. Think of exosomes as tiny delivery vehicles loaded with healing cargo.
5. Guided Delivery: Exosomes are released by stem cells and migrate to the site of the injured tissue. They’re like GPS-guided messengers, pinpointing the area that needs repair.
6. Healing Handover: Once at the injury site, exosomes attach themselves. Then comes the magic moment when they release their healing contents directly to the injured tissue.
The result? Remarkable tissue healing and regeneration. Stem cell-derived exosomes have shown incredible efficacy in various studies, from peripheral nerve damage and traumatic brain injury to wound healing, bone fusion, and more. They possess anti-inflammatory properties and play vital roles in skin, cartilage, and bone regeneration, making them versatile assets in regenerative medicine.
Despite their proven effects, it’s worth noting that, as of now, there are no FDA-approved exosome products available in the United States. Researchers continue to explore their potential and safety in clinical applications.
This is how stem cell-derived exosomes work their magic, offering promising avenues for cutting-edge therapies and tissue repair.
Tissue Regeneration & Remodeling
Exosomes derived from mesenchymal stem cells have been shown to reduce apoptosis (programmed cell death), which could lead to less tissue damage in response to disease or injury. MSC Exosomes have the capacity to enhance tissue remodeling by promoting a normal lattice-structure of collagen fibers for reduced scarring and more normal healing.
Figure 5 Healed incision after face lift with application Prism Exos® (lower) and without application of Prism ExosⓇ (upper).
FAQ
What is an exosome?
Exosomes are extracellular vesicles ranging between 30-150 nm that are produced by virtually every cell type as a means of intercellular communication They contain proteins (growth factors), mRNA (blueprint for protein production) and micro RNA (on-off switch for specific protein production), all contained within a membrane similar to their parent cells that protects exosomal proteins and RNA from degradation until they are delivered to the target cell.
Does the parent cell type of the exosome matter?
Yes, the cargo of the exosomes varies significantly according to the specific parent cell type. In this case, these MSC exosomes carry the developmental message of peri-natal mesenchymal stem cells, which are progenitor cells of the connective tissue lineage, meaning that they are involved in development of tissues like skin, hair, bones, muscle and cartilage.
How does Prism Exos compare to amniotic fluid?
Amniotic fluid has a significantly different protein profile than Prism Exos and lacks key proteins like TGF-B3, which is and important modulator of inflammation and immune function. Also, the exosomes present in amniotic fluid are primarly of maternal epithelial cell origin, which means that their cargo is substantially different than that of an MSC exosome.
How does Prism Exos compare to "stem cell" products often referred to as umbilical cord blood, Wharton's jelly or biologic allograft?
After thawing these frozen "stem cell" products, the viability of these allogeneic cells approaches zero, meaning that their effects are dependent on the growth factors and the low concentration of exosomes present in the product. Unlike Prism Exos, which has a very high concentration of MSC exosomes, these growth factors are not protected by the liposomal membrane.
Why Use Umbilical Cord Msc Derived Exosomes
Understanding the complexities and limitations of using live stem cells in medical treatments is crucial. Here’s an improved explanation:
Regulatory Complexity: Live stem cells carry significant medical risks, leading to stringent regulation. Presently, their lawful use is restricted to two scenarios: when derived from the patient’s own body or when they remain unaltered for tissue transplantation. However, these methods have inherent drawbacks beyond health risks.
1. Tissue Specificity: Tissues used for transplantation can only be applied to similar tissues. For instance, placental membranes are limited to skin-type tissues, restricting their versatility.
2. Aging and Diminished Efficacy: Self-derived stem cells are prone to age-related degradation. Typically, by the age of 40, the efficacy of a person’s stem cells starts declining. This decline is even more pronounced in patients around 60, precisely the age when many require stem cell therapies.
To overcome these limitations, we employ a cutting-edge approach:
Umbilical Cord Mesenchymal Stem Cells: We utilize umbilical cords from newborns to extract mesenchymal stem cells. These stem cells are exceptionally unique and potent.
Laboratory Control: These extracted cells undergo rigorous screening and culture in our state-of-the-art laboratory. This process ensures the safety and effectiveness of the cells.
Exosome Secretion: We immerse these stem cells in a carefully designed medium that prompts them to secrete exosomes. These exosomes contain consistent and abundant regenerative factors.
Quality Assurance: The exosomes are then extracted and subjected to batch testing. This meticulous analysis ensures their safety and effectiveness.
These exosomes, brimming with regenerative potential, become valuable tools for further research and innovative medical treatments. This approach addresses the limitations of live stem cell usage and offers promising avenues for advanced therapies.
Research results
“At Prism Exos, we take immense pride in being the exclusive representative of the only human umbilical cord-derived exosome company registered as a biological drug in the United States. What sets us apart is our unwavering commitment to the highest standards of safety and efficacy, coupled with rigorous testing and stringent FDA regulatory oversight.
Our dedication to excellence means that we offer the safest and most potent human umbilical cord-derived exosomes available on the market. Our exosomes are officially registered as a 351(a) biologic product, enabling us to offer them for research and investigational use. We go above and beyond in ensuring the quality of our product, subjecting it to comprehensive testing, and obtaining third-party virology reports to guarantee its safety and efficacy.
Our exosomes have garnered recognition for their positive impact across a wide spectrum of medical fields, including cardiology, aesthetics, plastic surgery, multiple sclerosis, cerebral palsy, and more. Studies affirm their effectiveness in treating cardiovascular disease by promoting angiogenesis and reducing inflammation. Additionally, our exosomes excel in promoting healing and reducing scarring in plastic surgery procedures. They have also exhibited remarkable potential in improving the symptoms of patients with conditions like multiple sclerosis, cerebral palsy, and stroke.
Beyond these areas, our exosomes have proven instrumental in enhancing sexual function in both men and women. Dr. Goldstein’s study underscores their role in improving erectile function and sexual desire in men with erectile dysfunction. Furthermore, our exosomes have demonstrated the ability to enhance vaginal lubrication and overall sexual function in women.
Choose Prism Exos for a transformative experience that brings the highest quality and innovation to regenerative medicine.”
In the field of aesthetics, our exosomes have been shown to improve skin texture, reduce wrinkles, and stimulate hair growth. In a study conducted by Dr. Berman, our exosomes were found to stimulate hair growth in patients with androgenetic alopecia.
Furthermore, our exosomes have been shown to have neuroprotective effects and can promote nerve regeneration in conditions such as optic nerve damage and glaucoma. Studies have also shown that our exosomes can improve symptoms in patients with COVID-19 long-haulers and dementia.
In orthopedics, our exosomes have been shown to reduce inflammation and promote cartilage regeneration, making them effective in treating arthritis and other joint-related conditions. Our exosomes have also been shown to improve outcomes in spinal cord injuries.
We take pride in the quality of our product and the studies that support its efficacy. Our exosomes are the result of years of research and development, and we are committed to providing thehighest quality product to our customers. To learn more about the studies mentioned above, please see the links below:
- Cardio Vacular Diseases.
- Plastic Surgery
- Multiple Sclerosis
- Stroke
- Sexual Dysfunction
- Aesthetics
- Optic Nerve Damage Glaucoma
- Covid Long haulers
- Dementia and Alzheimers
- Arthritis
- Spinal Cord Injuries
- Osteoarthritis
Future Products
We are pursuing the following future product lines and are looking forward to getting appropriate FDA clearances to allow sales and distribution of these products soon.
ADDITIVE:
For FDA Devices/saline.
EAR DROPS:
Dropper bottle with calibrated dropper
EYE DROP:
Case of 20x 5ml eye droppers
CLINICAL INHALATION:
Dropper bottle for use with a nebulizer
TOPICAL (CREAM/LOTION/SERUM):
Packaging to be determined
HOME USE INHALATION:
Pressurized Inhaler
WOUND CARE:
Hydro Gel in a medical spray, possibly coupled with a bandage S
NASAL SPRAY:
Spray Bottle For Nasal Inhalation
DERMATOLOGY/AESTHETIC FOR POST-SKIN TREATMENT:
Spray Specialized applicator
VAGINAL USE:
Utilizing Hydro Gel
